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San Francisco 49ers at Kansas City Chiefs

Kansas City Chiefs vs San Francisco 49ers head-to-head

NFLWeek 16 • regular • 2026
Scheduled
Chiefs logo
Chiefs
Kansas City
0
vs
49ers logo
49ers
San Francisco
0
KC 53%47% SF
Prediction Confidence:
High

Kansas City Chiefs 53% to win. The biggest signal favoring Chiefs:

  • Home Field Advantage. Chiefs are 3-0 at home this season; 49ers are 2-0 on the road

What would change the call

Win probability if a leading factor were even

  • If the home-field edge were neutral: KC 50% (−3)
  • If the rating edge were neutral: KC 55% (+2)

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VenueArrowhead Stadium
Kansas City, MO

Team Comparison

Head-to-head snapshot based on our model inputs

49ers (away)
Chiefs (home)
47%
Win probability
53%
0
High-impact factors
0
0
Players ruled out
0

Game Preview

49ers at Chiefs

The 49ers visit the Chiefs at Arrowhead Stadium in Kansas City, MO in NFL regular season Week 16 action.

Our model gives the Chiefs a 53% chance of winning, making this an extremely close matchup. For the 49ers to win, several key factors would need to swing their way.

Key factors driving this prediction:

  • Home Field Advantage favors the Chiefs (medium): Chiefs are 3-0 at home this season; 49ers are 2-0 on the road
  • ELO Rating favors the 49ers (low): Chiefs ELO 1534 vs 49ers ELO 1596 (diff: -62)
  • Defensive Efficiency is neutral: Defensive efficiency stats not yet available
Chiefs53%

is slightly favored to win

Key Factor
Home Field Advantage
Favors KC

Key Factors

What's driving the win probability for this game

  • Home Field AdvantageFavors Kansas City Chiefs
  • ELO RatingFavors San Francisco 49ers
  • Defensive EfficiencyNeutral
  • Recent FormNeutral
  • Rest DaysNeutral
  • Weather ImpactNeutral
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What's Driving This Game

Each factor's contribution to the final win probability

SF
KC
Home Field Advantage
ELO Rating
Favours SF|Favours KC

Premium feature: factor breakdown

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Understanding the win probability calculation

3 factors not shown (insufficient data)

Model version: 1.1.0 • Calculated: 10/25/2026, 11:26:40 AM

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Key Players

49ers

Adrian MartinezQB
Kurtis RourkeQB
Mac JonesQB
Brock PurdyQB
Deebo Samuel Sr.WR

Chiefs

Justin FieldsQB
Chris OladokunQB
Garrett NussmeierQB
Patrick MahomesQB
Justin WatsonWR

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Next and previous games for each team, plus others from this week. Win probabilities use the same display assessment as the game page.

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Frequently Asked Questions

Chiefs has a 53% win probability, while 49ers has a 47% win probability based on our analysis.

Our model considers weather conditions, offensive and defensive efficiency, rest days, injury impact, and historical performance.

This game is being played at Arrowhead Stadium in Kansas City, MO.

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