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San Francisco 49ers at Arizona Cardinals

Arizona Cardinals vs San Francisco 49ers head-to-head

NFLWeek 18 • regular • 2026
Scheduled
Cardinals logo
Cardinals
Arizona
0
vs
49ers logo
49ers
San Francisco
0
ARI 43%57% SF
Prediction Confidence:
High

San Francisco 49ers 57% to win. The top 2 signals favoring 49ers:

  • ELO Rating. Cardinals ELO 1412 vs 49ers ELO 1596 (diff: -184)
  • Home Field Advantage. Cardinals are 0-2 at home this season; 49ers are 2-0 on the road (divisional game, reduced advantage)

What would change the call

Win probability if a leading factor were even

  • If the rating edge were neutral: SF 50% (−7)
  • If the home-field edge were neutral: SF 55% (−2)

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VenueState Farm Stadium
Glendale, AZ

Team Comparison

Head-to-head snapshot based on our model inputs

49ers (away)
Cardinals (home)
57%
Win probability
43%
0
High-impact factors
0
0
Players ruled out
0

Game Preview

49ers at Cardinals

The 49ers visit the Cardinals at State Farm Stadium in Glendale, AZ in NFL regular season Week 18 action.

Our model gives the 49ers a 57% chance of winning, making this a competitive contest. For the Cardinals to win, several key factors would need to swing their way.

Key factors driving this prediction:

  • ELO Rating favors the 49ers (medium): Cardinals ELO 1412 vs 49ers ELO 1596 (diff: -184)
  • Home Field Advantage favors the 49ers (low): Cardinals are 0-2 at home this season; 49ers are 2-0 on the road (divisional game, reduced advantage)
  • Turnover Differential is neutral: Cardinals turnover differential (+0) vs 49ers (+0)
49ers57%

is favored to win

Key Factor
ELO Rating
Favors SF

Key Factors

What's driving the win probability for this game

  • ELO RatingFavors San Francisco 49ers
  • Home Field AdvantageFavors San Francisco 49ers
  • Turnover DifferentialNeutral
  • Head to HeadNeutral
  • InjuriesNeutral
  • Offensive EfficiencyNeutral
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What's Driving This Game

Each factor's contribution to the final win probability

SF
ARI
ELO Rating
Home Field Advantage
Favours SF|Favours ARI

Premium feature: factor breakdown

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Understanding the win probability calculation

3 factors not shown (insufficient data)

Model version: 1.1.0 • Calculated: 10/25/2026, 11:26:41 AM

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Key Players

49ers

Adrian MartinezQB
Brock PurdyQB
Kurtis RourkeQB
Mac JonesQB
Christian KirkWR

Cardinals

Jacoby BrissettQB
Gardner Minshew IIQB
Carson BeckQB
Simi FehokoWR
Reggie VirgilWR

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Frequently Asked Questions

Cardinals has a 43% win probability, while 49ers has a 57% win probability based on our analysis.

Our model considers weather conditions, offensive and defensive efficiency, rest days, injury impact, and historical performance.

This game is being played at State Farm Stadium in Glendale, AZ.

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